Critical Immune Defense

Rated 4.7 out of 5
Based on 995 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions & orders $75 or more.

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Your Pet's Immune System Is the Key to Its Health

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet. Let’s face it. Your dog and cat lives in a world filled with contamination. They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants. The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful.

    Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health. Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

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    50%

    Cancer Rates are skyrocketing

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    The doctors agree

    Dr. Frank Markland

    Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine.

    Dr. Shawn Messonnier

    Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

    Dr. Jennifer Edwards

    Ponemah Veterinary Hospital

    Where you have seen us

    Critical Immune Defense

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    The all-natural solution. Trusted by veterinarians.

    Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

    Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Frequently Asked Questions

    Happy Customer Reviews

    average rating 4.7 out of 5
    Based on 995 reviews
    • 5 Stars
      822 Reviews
    • 4 Stars
      104 Reviews
    • 3 Stars
      48 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      14 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Customer photos and videos
    995 Reviews
    Reviewed by Bethany G.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Hip Pain
    • Joint Pain

    CID the best!

    CID in my opinion has improved my Meeka”s health in many ways. It has shrunk fatty cysts,and growth she had on her head. Also she is 12 y.o. and after reading all the reviews I will continue to give it to her hopefully for a few more years.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Bethany, thank you for your fantastic review! We're thrilled that CID has helped shrink Meeka's cysts and growths. At 12 years old, it's wonderful to hear she's feeling better. Your dedication to her health is inspiring. Meeka looks adorable in her picture! 🐾🐶

    Reviewed by Jennifer C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    English Bulldog
    Pet Problem(s)
    • Cancer

    So far very good!!

    I have been impressed with Lulu’s comfort level of breathing at night since taking this product. We will continue.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Jane, thank you for your lovely review! We're so happy that Critical Immune Defense has helped Lulu breathe better at night. She's a beautiful English Bulldog at six years old, and her progress is heartwarming 🐾. We're here to support you both every step of the way! 🐶🌟

    Reviewed by Jean D.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Poodle
    Pet Problem(s)
    • Low Energy
    • Joint Pain

    It's working!

    Our Standard Poodle Rosie will be 15 next November. We started her on the Critical Immune Defense 6 months ago because she was really slowing down on her daily walks. She definitely has more energy now and sometimes even wants to play... running through the house playing keep-a-way with her favorite toy. She's been deaf for about 2 years and her cataracts are bad. But we use hand signals and she is always ready to go for a walk or ride. We definitely see a difference in her energy. Last fall we didn't think she would be with us for Christmas!! She won us second 🥈 place in the Golf Cart Christmas Parade in our 55 and over park in Florida. The second picture is at home in Illinois.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Thank you, Jean, for sharing Rosie's uplifting story!! It's wonderful to hear how the Critical Immune Defense has revitalized her, bringing more play and energy into her golden years. Despite her hearing and sight challenges, her festive spirit clearly shines, especially with that second-place win in the Christmas parade! She looks absolutely adorable in her photo. Here's to many more joyful moments with your spirited senior gal, Rosie! 🌟🐾

    Reviewed by Patty J.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Groodle
    Pet Problem(s)
    • Tumor
    • Inflammation

    Helping with lipomas!???

    I’m trying this for my 10+year old golden doodle. He has an unusual elbow bursitis type condition that even the veterinarians are unsure of! So far it has swollen and then reduced before… but it has reduced since he has been eating the immune defense powder. I plan to keep trying it and hopefully he will not have more inflammation!!

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Patty, thank you for your positive review and for sharing your Golden Doodle's progress! It's encouraging to hear that our Critical Immune Defense powder is helping with his unusual elbow condition. We're thrilled to see the inflammation reduce and hope for continued improvement. Keep us posted on his journey—here’s to more comfortable days ahead! 🐾🌟

    Reviewed by Claudia H.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Pitbull Terrier
    Pet Problem(s)
    • Tumor
    • Cancer

    Critical Immune Defense

    Rhino had a cancerous tumor on his spleen and we had to have it removed. He was 10 at the time. The doctor gave him another 4-6 months to live and I happy to say he will be celebrating his 12th birthday soon! Critical Immune Defense is part of the vitamin regimen we put him on because of its cancer fighting properties and we couldn't be happier.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Thank you for sharing Rhino's incredible journey and his adorable photo! It’s heartwarming to hear how well he’s doing after his diagnosis, especially as he approaches his 12th birthday. We’re thrilled that our Critical Immune Defense is helping him thrive. Here’s to more healthy, happy years for Rhino! 🎉🐾